2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141186
    TCO-OH 85081-69-2 99.91%
    TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-OH
  • HY-141106
    m-PEG12-NHS ester 2207596-93-6 98.0%
    m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-NHS ester
  • HY-W096120
    Azide-PEG3-Desthiobiotin 1426828-06-9
    Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Desthiobiotin
  • HY-133388
    Boc-NH-C12-NH2 109792-60-1 98.0%
    Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C12-NH2
  • HY-21999
    tert-Butyl 6-aminocaproate 5514-98-7 99.96%
    tert-Butyl 6-aminocaproate (Tert-butyl 6-aminohexanoate) is a PROTAC linker. tert-Butyl 6-aminocaproate can be used in synthesis PROTAC CARM1/IKZF3 degrader-1 (HY-172368).
    tert-Butyl 6-aminocaproate
  • HY-W092043
    TLR4-IN-C34-C2-COOH 1159408-54-4 99.94%
    TLR4-IN-C34-C2-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34 (HY-107575). TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    TLR4-IN-C34-C2-COOH
  • HY-W018365
    Tetraethylene glycol monomethyl ether 23783-42-8 99.61%
    Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethylene glycol monomethyl ether
  • HY-140216
    Azido-PEG8-amine 857891-82-8 99.87%
    Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-amine
  • HY-69220
    7-Octynoic acid 10297-09-3 98.0%
    7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7-Octynoic acid
  • HY-140888
    Biotin-PEG2-NHS ester 596820-83-6
    Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-NHS ester
  • HY-140757
    Azido-PEG5-NHS ester 1433996-86-1 ≥98.0%
    Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-NHS ester
  • HY-W004710
    NH2-C5-NH-Boc 51644-96-3 99.88%
    NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C5-NH-Boc
  • HY-30756
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate 236406-55-6 99.89%
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332).
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate
  • HY-140273
    DBCO-PEG8-NHS ester 2553412-88-5 98.34%
    DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-NHS ester
  • HY-W034595
    Eicosanedioic acid 2424-92-2 99.0%
    Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
    Eicosanedioic acid
  • HY-W040238
    Fmoc-NH-PEG2-CH2CH2COOH 872679-70-4 99.79%
    Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG2-CH2CH2COOH
  • HY-W004701
    Br-C3-methyl ester 4897-84-1 99.12%
    Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    Br-C3-methyl ester
  • HY-140676
    mPEG-amine (MW 2000) 80506-64-5 99.57%
    mPEG-amine (mPEG-NH2) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-amine (MW 2000)
  • HY-140314
    DOTA-PEG5-C6-DBCO
    DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DOTA-PEG5-C6-DBCO
  • HY-140698
    m-PEG-NHS ester (MW 5000) 92451-01-9
    m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-NHS ester (MW 5000)
PROTAC Linkers Isoform Comparison

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